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KMID : 1059520140580040388
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Journal of the Korean Chemical Society
2014 Volume.58 No. 4 p.388 ~ p.392
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Microwave-Assisted and Conventional Synthesis of Benzothieno [3,2-e] [1,3,4] triazolo[4,3-c]pyrimidines: A Comparative Study
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Gaonkar Santhosh L.
Ahn Chul-Jin
Princia
Shetty Nitinkumar S.
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Abstract
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Benzothieno[2,3-d]pyrimidines (2,3,4) and benzothieno[3,2-e][1,3,4]triazolo[4,3-c] pyrimidines (5a-c) were synthesized from the precursor 2-amino-7-oxo-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile 1 by employing the conventional method as well as the microwave irradiation technique. The precursor 2-amino-3-cyanothiophene analogue 1 was synthesized by employing the well-known Gewald reaction. In the present work it has been found that the microwave supported syntheses are more efficient than the conventional classical heating methods. The structures of all the compounds were ascertained by spectral and analytical data.
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KEYWORD
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Conventional method, Microwave irradiation, Thienopyrimidine, Triazolothienopyrimidine
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